Preliminary study on proteomic patterns in hepatic tissue to identify HBV related hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 231-233, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-260052
ABSTRACT
<p><b>OBJECTIVE</b>To identify proteomic patterns in hepatic tissues for diagnosing early HBV related HCC.</p><p><b>METHODS</b>Proteomic spectra were generated by two-dimensional gel electrophoresis (2-DE), A preliminary "raining" set of spectra derived from analysis of 14 cancer tissues and 14 non-cancer tissues, a proteomic patterns that completely discriminated cancer from non-cancer was identified. The discovered pattern was then used to classify an independent set of 48 masked samples 24 from cancer tissues, and 24 from non-cancer tissues.</p><p><b>RESULTS</b>The discriminatory pattern correctly identified all cancer tissues and non-cancer tissues in the masked set. This result yielded a sensitivity of 100%, specificity of 100%.</p><p><b>CONCLUSION</b>Further analysis on these proteins in the proteomic pattern will be helpful to screen tumor markers for HBV related HCC. These findings justify a prospective assessment of proteomic pattern technology as a screening tool for cancer in high-risk and general populations.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Química
/
Carcinoma Hepatocelular
/
Proteômica
/
Diagnóstico
/
Hepatite B
/
Fígado
/
Neoplasias Hepáticas
/
Proteínas de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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