Comparative studies of casein phosphopeptide-amorphous calcium phosphate and fluoride products in inhibiting enamel demineralization / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and several fluoride products in inhibiting enamel demineralization.</p><p><b>METHODS</b>Seventy healthy premolars extracted before orthodontic treatment were divided into seven groups (A CPP-ACP; B CPP-ACP + fluoride mouth rinses; C fluoride mouth rinses; D fluoride glass ionomer protection; E fluoride resin binder; F fluoride varnish; G control group). There were ten samples in each group. The teeth were dipped into an artificial caries solution ten minutes at a time, then applied separately with CPP-ACP, CPP-ACP + fluoride mouth rinses, fluoride mouth rinses, fluoride glass ionomer protection, fluoride resin binder and fluoride varnish on labial enamel. The samples were dipped into an artificial saliva solution (37°C). Then all samples were examined with atomic force microscope (AFM) at the end of first, second and third monthes.</p><p><b>RESULTS</b>At the end of the first month, surface roughness in group D [(114 ± 1) nm] was significantly lower than that in group G[(172 ± 9) nm]. At the end of the second month and the third month, significant difference was found in surface roughness between group G and the rest of groups (P < 0.05); between group B and the rest of groups; and between group C and groups (D, E and F).</p><p><b>CONCLUSIONS</b>CPP-ACP and fluoride could both inhibit enamel demineralization in vitro. Solid fluoride (groups D, E and F) had better results than liquid fluoride (group C).</p>