Correlations of three important technological parameters in first ethanol precipitation of Danshen / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3274-3277, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-260673
ABSTRACT
<p><b>OBJECTIVE</b>Water content in concentrated extract (WCCE), the concentration of ethanol used in precipitation (CEA) and the quantity of ethanol added( QEA) are three important variables in the first ethanol precipitation of Danshen injection. In this work, the relationships between the three variables and total solid removal, Danshensu (DSS)retention and DSS purity were investigated.</p><p><b>METHOD</b>Experiments according to central composite design were carried out and mathematical models were developed.</p><p><b>RESULT</b>The models were accurate and predictive. The relative deviations between prediction results and experimental results were less than 3%. The influences of the three variables were discussed with a response surface method. The decrease of WCCE and the increase of CEA both caused more precipitation and increase the purity of DSS. However, more loss of DSS was observed. The increase of QEA increased total solid removal. DSS retention and DSS purity increased first and then decreased when QEA increased.</p><p><b>CONCLUSION</b>This result suggests the addition of ethanol should be optimized according to WCCE and CEA to obtain better supernatant</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Precipitação Química
/
Água
/
Química
/
Reprodutibilidade dos Testes
/
Modelos Estatísticos
/
Salvia miltiorrhiza
/
Etanol
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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