Protective effects of xuefu zhuyu decoction on myocardium ischemia reperfusion injury in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3077-3079, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-260683
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effects of Xuefu Zhuyu decoction on myocardium ischemia reperfusion injury in rats.</p><p><b>METHOD</b>36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury.</p><p><b>RESULT</b>Compared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group.</p><p><b>CONCLUSION</b>Xuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Traumatismo por Reperfusão Miocárdica
/
Distribuição Aleatória
/
Interleucina-6
/
Interleucina-10
/
Ratos Sprague-Dawley
/
Substâncias Protetoras
/
Usos Terapêuticos
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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