Research on phytoestrogenic effect of formononetin / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3060-3064, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-260687
ABSTRACT
<p><b>OBJECTIVE</b>Research on the phytoestrogenic effect and its possible mechanism of formononetin.</p><p><b>METHOD</b>To evaluate the estrogenic effect and mechanisms of formononetin through the test of its influence on proliferation and ER subtype expression of T47D cells.</p><p><b>RESULT</b>The proliferation rates of T47D cells treated with 1 x 10(-7) -1 x 10(-6) mol x L(-1) formononetin were not increased. On the influence of ICI182, 780, the proliferation rates of T47D cells treated with 1 x 10(-7) 1 x 10(-6) mol x L(-1) formononetin were decreased. Formonenetin could induce the augment of ERalpha expression significantly of T47D.</p><p><b>CONCLUSION</b>Formonenetin has phytoestrogenic effect Formonenetin can not accelerate ER(+) T47D cell proliferation. But the expression level of ERalpha subtype in T47D cells change significantly with certain concentrations of formonenetin.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Neoplasias da Mama
/
Receptores de Estrogênio
/
Linhagem Celular Tumoral
/
Fitoestrógenos
/
Proliferação de Células
/
Tratamento Farmacológico
/
Genética
/
Isoflavonas
/
Metabolismo
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
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