Preparation and in vitro drug release of ferulic acid loaded chitosan microspheres containing liposomes / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2972-2975, 2010.
Article
em Zh
| WPRIM
| ID: wpr-260707
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To construct the ferulic acid loaded chitosan microspheres containing liposomes.</p><p><b>METHOD</b>Ferulic acid was selected to be the model drug. Liposomes were prepared by calcium acetate gradient method. The entrapment efficiency of liposomes was(79.97 +/- 0.54)%, the average size was (187.6 +/- 11.9) nm and the Zeta potential was -12.67 +/-1.78. The chitosan microspheres, whose entrapment efficiency was (57.89 +/- 1.72)%, were prepared by onic gelation method after liposomes were mixed with chiotosan solution. Ferulic acid was entrapped in liposomes in amorphous form and then liposomes were distributed in microspheres intactly.</p><p><b>RESULT</b>The 80.97% liposomes were released from microspheres and the 32.33% ferulic acid was released from microspheres at 12 h, which was much slower than simple chitosan microspheres.</p><p><b>CONCLUSION</b>This study demonstrated that chitosan microspheres containing liposomes have good sustained-releasing property in vitro.</p>
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1
Índice:
WPRIM
Assunto principal:
Tamanho da Partícula
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Farmacocinética
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Cinética
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Química
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Química Farmacêutica
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Ácidos Cumáricos
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Preparações de Ação Retardada
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Quitosana
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Composição de Medicamentos
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Lipossomos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Article