Serum metabolome analysis reveals effect of panax notoginosides on ischemic rat after acute myocardial infarction / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>The effect of panax notoginosides on ischemic rat after acute myocardial infarction by coronary artery ligation was preliminarily investigated using metabonomics approach.</p><p><b>METHOD</b>GC-MS based metabonomics approach was applied to analyse the serum metabolome of normal group, model group and treatment group of rats. Furthermore, PCA and PIS-DA was used to identify the differentially expressed metabolites among the three groups.</p><p><b>RESULT</b>A good fit and prediction results using metabolome data was obtained by PCA and PL-DA. Moreover, 10 metabolites were selected as potential biomarkers for efficacy evaluation of panax notoginosides by t-test and variable importance in the projection.</p><p><b>CONCLUSION</b>Metabonomics provides a whole-organism biological description of pathological or physiological state, and likely can be used as a new approach for efficacy evaluation of traditional Chinese medicine.</p>