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Association of HLA-A0205 and HLA-A30 with latent autoimmune diabetes in adults / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 1089-1094, 2010.
Artigo em Chinês | WPRIM | ID: wpr-260932
ABSTRACT
To investigate the association of HLA-A0205 and HLA-A30 with latent autoimmune diabetes mellius in adults (LADA) in Chengdu Hans, 121 subjects (41 cases of LADA, 40 cases of T2DM, and 40 normal controls) were enrolled in the study. The frequencies of HLA-A0205 and HLA-A30 were determined by nested PCR-SSP and direct sequencing, respectively. The allele frequencies of patient groups and of normal controls were compared by chi-square test using SPSS 11.0 (alpha = 0.05). Hardy-Weinberg equilibrium was tested with use of software HWE (alpha = 0.05). Data from the subjects showed HLA-A0205 was present in 1 patient with LADA and in 1 normal control (2.44% and 2.5%, respectively), HLA-A30 was present in 2 patients with LADA, in 2 patients with T2DM and in 1 normal control (4.87%, 5.0% and 2.5%, respectively). There was no statistically significant difference between the allele frequencies of the three groups. These results suggest that HLA-A0205, HLA-A30 may not be related to LADA in Chengdu Hans. Yet, further studies with larger sample size may be needed to warrant this conclusion.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doenças Autoimunes / Antígenos HLA-A / Estudos de Casos e Controles / China / Reação em Cadeia da Polimerase / Idade de Início / Polimorfismo Conformacional de Fita Simples / Diabetes Mellitus / Genética / Genótipo Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Chinês Revista: Journal of Biomedical Engineering Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doenças Autoimunes / Antígenos HLA-A / Estudos de Casos e Controles / China / Reação em Cadeia da Polimerase / Idade de Início / Polimorfismo Conformacional de Fita Simples / Diabetes Mellitus / Genética / Genótipo Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Chinês Revista: Journal of Biomedical Engineering Ano de publicação: 2010 Tipo de documento: Artigo