Changes in pain threshold and glial cell line-derived neurotrophic factor in rat model of trigeminal neuralgia / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 16-20, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-261146
ABSTRACT
<p><b>OBJECTIVE</b>This research aims to study the changes in pain threshold and glial cell line-derived neurotrophic factor (GDNF) in a Sprague Dawley (SD) rat model oftrigeminal neuralgia.</p><p><b>METHODS</b>A total of 36 male SD rats were randomly divided into three groups operative, sham-operative, and control. In the operative group, a chronic constriction injury (CCI) was caused by placing loose chromic gut ligatures around the right infraorbital nerve (ION). In the sham-operative group, the right ION was subjected to the same procedure, but without ligation. In the control group, the right ION was not subjected to any treatment. The pain thresholds of the three groups were recorded at different times after the operation. The GDNF expression in each group was analyzed via immunohistochemical staining.</p><p><b>RESULTS</b>An allodynia to mechanical stimulation in the region of the ligated ION was observed starting on the 2nd week after operation. Pain thresholds started to increase gradually from the 6th week and returned to the original level at the 10th to 12th week after operation. Cells that expressed the GDNF markedly increased in number in the operative group with changes observed at different times.</p><p><b>CONCLUSION</b>We use chronic constriction injury to the infraorbital nerve (CCI-ION) to establish a trigeminal neuralgia-like animal model in SD rats. GDNF may play a role in regulating pain by promoting the restoration and regeneration of nerve fibers.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neuralgia do Trigêmeo
/
Ratos Sprague-Dawley
/
Limiar da Dor
/
Constrição
/
Modelos Animais de Doenças
/
Fatores Neurotróficos Derivados de Linhagem de Célula Glial
/
Fator Neurotrófico Derivado de Linhagem de Célula Glial
/
Hiperalgesia
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS