Influence of delayed cord clamping on preterm infants with a gestational age of <32 weeks / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the influence of delayed cord clamping (DCC) on preterm infants with a gestational age of <32 weeks.</p><p><b>METHODS</b>Ninety preterm infants with a gestational age of <32 weeks delivered naturally from January to December, 2015 were enrolled and randomly divided into DCC group (46 infants) and immediate cord clamping (ICC) group (44 infants). The routine blood test results, total amount of red blood cell transfusion, blood gas parameters, mean arterial pressure, bilirubin peak, total time of phototherapy, and incidence rates of necrotizing enterocolitis, late-onset sepsis, intracranial hemorrhage, retinopathy, and bronchopulmonary dysplasia were compared between the two groups.</p><p><b>RESULTS</b>Compared with the ICC group, the DCC group had significantly higher levels of hemoglobin, hematocrit, mean arterial pressure, and standard base excess (P<0.05), as well as a significantly lower percentage of preterm infants who underwent volume expansion and dopamine treatment and a significantly lower amount of red blood cell transfusion (P<0.05). The body temperature, pH value, HCO3(-) concentration, serum bilirubin peak, total time of phototherapy, and incidence rates of late-onset sepsis, retinopathy, grade≥2 intracranial hemorrhage, and grade≥2 neonatal necrotizing enterocolitis showed no significant differences between the two groups (P>0.05).</p><p><b>CONCLUSIONS</b>DCC is a safe clinical intervention and can improve the prognosis of preterm infants with a gestational age of <32 weeks.</p>