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Immunophenotype and differential diagnosis of Hodgkin's lymphoma / 中华血液学杂志
Chinese Journal of Hematology ; (12): 524-527, 2002.
Article em Zh | WPRIM | ID: wpr-261389
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the immunophenotype and differential diagnosis of Hodgkin's lymphoma (HL).</p><p><b>METHOD</b>Fifty six cases originally diagnosed as HL were re-evaluated according to lymphoma classification of WHO 2000 on paraffin sections using SP immunohistochemistry.</p><p><b>RESULTS</b>Among the 56 cases, 47 met the WHO criteria for HL, 8 were NHL and 1 metastatic tumor. Of the 47 HL cases, 2 were nodular lymphocyte predominant HL (NLPHL), 43 classical Hodgkin's lymphoma (CHL) and 2 unclassified HL, and of the 8 cases reclassified as NHL, 6 were T-cell rich B-cell lymphoma (TCRBCL) and 2 anaplastic large cell lymphoma (ALCL). In NLPHL cases, L&H cells were CD(20)(+), CD(15)(-) and CD(30)(-); CD(57)(+) cells and small B-lymphocytes predominated the background infiltration. Diagnostic R-S cells and other tumor cells in 43 cases of CHL were positive for CD(30) (100%), CD(15) (81%) and CD(20) (7%). Six cases of TCRBCL were negative for CD(15) and CD(30). Two cases of ALCL were positive for CD(30), ALK-1 and CD(3), and negative for CD(15) and CD(20). The reactive inflammatory infiltration in CHL and TCRBCL was rich in TIA-1 positive cytotoxic lymphocytes, and CD(57)(+) cells were rarely encountered.</p><p><b>CONCLUSION</b>Combining the immunophenotype of tumor cells and background cells with morphologic criteria are more helpful for classification of HL, and discrimination between NLPHL, CHL and TCRBCL.</p>
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Doença de Hodgkin / Imuno-Histoquímica / Proteínas / Antígenos CD / Imunofenotipagem / Proteínas de Ligação a RNA / Mucina-1 / Proteínas de Ligação a Poli(A) / Diagnóstico Diferencial Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: Zh Revista: Chinese Journal of Hematology Ano de publicação: 2002 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Doença de Hodgkin / Imuno-Histoquímica / Proteínas / Antígenos CD / Imunofenotipagem / Proteínas de Ligação a RNA / Mucina-1 / Proteínas de Ligação a Poli(A) / Diagnóstico Diferencial Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: Zh Revista: Chinese Journal of Hematology Ano de publicação: 2002 Tipo de documento: Article