Expression of cell adhesion molecules in acute leukemia cell / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 581-584, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-261396
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of cell adhesion molecule in the development and extramedullary infiltration (EI) of acute leukemia.</p><p><b>METHODS</b>The expressions of neural cell adhesion molecule (NCAM) gene, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) genes in 25 acute leukemia patients bone marrow cells were detected by microarray and reverse transcriptase-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>The expressions of NCAM, ICAM-1 and VCAM-1 gene were significantly higher in acute leukemia cells and leukemia cells with EI than in normal tissues and leukemia cells without EI, respectively, both by cDNA microarray and by RT-PCR.</p><p><b>CONCLUSION</b>The cDNA microarray is a powerful technique in analysis of acute leukemia cells associated genes. High expressions of cell adhesion molecule genes might be correlated with leukemia pathogenesis and infiltration of acute leukemia cell.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
RNA Mensageiro
/
Células da Medula Óssea
/
Leucemia Mieloide
/
Moléculas de Adesão Celular
/
Regulação Neoplásica da Expressão Gênica
/
Doença Aguda
/
Molécula 1 de Adesão Intercelular
/
Molécula 1 de Adesão de Célula Vascular
/
Moléculas de Adesão de Célula Nervosa
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2002
Tipo de documento:
Artigo
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