Study on the relationship between Gln223arg variant in leptin receptor gene and obesity / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association between Gln223Arg variant in leptin receptor (LEPR) gene and obesity.</p><p><b>METHODS</b>The subjects were from Yu county, Shanxi province, China. Data on cardiovascular risk factors was collected with questionnaire and their Gln223Arg variants in LEPR gene were genotyped. The relation between Gln223Arg variant in LEPR and obesity was analyzed.</p><p><b>RESULTS</b>The genotype frequencies of G. G, G. A and AA were 0.7679, 0.2171 and 0.015 respectively and the allele frequencies of G and A were 0.8764 and 0.1236. The distribution of genotype was in Hardy-Weinberg equilibrium (P = 0.934). The results of single factor analysis showed that the carriers with the Arg223 alleles had higher weight (63.2 kg vs. 61.9 kg; P= 0.0307) and body mass index (24.4 kg/rn vs. 24.1 kg/m2; P = 0.0898) than those noncarriers of these alleles. Results from multivariate analysis indicated that the carriers with the Arg223 alleles had higher body mass index (24.5 kg/m2 vs. 24.1 kg/m ;P= 0.0396) and prevalence of obesity (OR = 1.30, 95% CI 0.957-1.767; P= 0.0935).</p><p><b>CONCLUSION</b>These data indicated that Gln223Arg variant in LEPR gene was possibly associated with obesity, respectively.</p>