PML-RARα and p21 are key factors for maintaining acute promyelocytic leukemia stem cells survival / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1299-1302, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-261880
ABSTRACT
Tumor stem/progenitor cells are the cells with the characteristics of self-renewal, differentiating to all the other cell populations within tumor, which are also regarded as the source of tumor relapse, drug-resistance and metastasis. As a subtype of acute myeloid leukemia, acute promyelocytic leukemia (APL) represents the target of therapy due to the good response of the oncogenic protein PML-RARα to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). This review summarizes the latest research results of APL as follows (1) there probably are two APL stem/progenitor cell populations within APL, and self-renewal and survival of APL stem/progenitor cells highly depend on PML-RARα expression, cell cycle inhibitor p21, self-renewal associated molecules and chemokines; and (2) ATRA and ATO eradicate APL stem/progenitor cells mainly by PML-RARα degradation, FOXO3A activation and the inhibition of self-renewal-associated signaling pathway of sonic hedgehog. These findings are helpful to improve other tumor therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Células-Tronco Neoplásicas
/
Células Tumorais Cultivadas
/
Leucemia Promielocítica Aguda
/
Transdução de Sinais
/
Proteínas de Fusão Oncogênica
/
Sobrevivência Celular
/
Biologia Celular
/
Inibidor de Quinase Dependente de Ciclina p21
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2011
Tipo de documento:
Artigo
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