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The role of PDGF/PDGFR in the regulation of platelet formation / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1097-1101, 2011.
Artigo em Chinês | WPRIM | ID: wpr-261922
ABSTRACT
Platelet-derived growth factor (PDGF), a potent chemotactic and mitogenic factor, is involved in the regulation of hematopoiesis and platelet production. Our studies demonstrate the presence of functional PDGF receptors (PDGFR) on human megakaryocytes/platelets and CD34(+) cells, and their ability to mediate a mitogenic response. PDGF promotes the ex vivo expansion of human hematopoietic stem (CD34(+)) and progenitor (CD41(+)) cells. More significantly, PDGF enhances the engraftment of human CD45(+) cells and their myeloid subsets (CD33(+), CD14(+) cells) in NOD/SCID mice. PDGF also stimulates in vitro megakaryocytopoiesis via PDGFR and/or the indirect effect on bone marrow microenvironment to produce TPO and other cytokines. It also shows a direct stimulatory effect of PDGF on c-Fos, GATA-1 and NF-E2 expressions in megakaryocytes. We speculate that these transcription factors may be involved in the signal transduction of PDGF on the regulation of megakaryocytopoiesis. PDGF also enhances platelet recovery in mouse model with radiation-induced thrombocytopenia. This radioprotective effect is likely to be mediated via PDGFR with subsequent activation of the PI3K/Akt pathway. It provides a possible explanation that blockage of PDGFR may reduce thrombopoiesis and play a role in imatinib mesylate-induced thrombocytopenia.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fator de Crescimento Derivado de Plaquetas / Células-Tronco Hematopoéticas / Megacariócitos / Receptores do Fator de Crescimento Derivado de Plaquetas / Biologia Celular / Trombopoese / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fator de Crescimento Derivado de Plaquetas / Células-Tronco Hematopoéticas / Megacariócitos / Receptores do Fator de Crescimento Derivado de Plaquetas / Biologia Celular / Trombopoese / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2011 Tipo de documento: Artigo