Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma
Annals of Pediatric Endocrinology & Metabolism
;
: 150-154, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-26215
ABSTRACT
PURPOSE:
Osteoporosis is currently receiving particular attention as a sequela in survivors of childhood osteosarcoma. The aim of this study was to evaluate bone mineral density (BMD) changes during methotrexate-based chemotherapy in children and adolescents with osteosarcoma.METHODS:
Nine patients with osteosarcoma were included in this retrospective study and compared with eight healthy controls. BMD of the lumbar spine and unaffected femur neck of patients was serially measured by dual-energy x-ray absorptiometry (DXA) before and just after chemotherapy and compared with controls.RESULTS:
Four patients (44%) showed decreased lumbar spine BMD and seven patients (78%) showed decreased femur neck BMD, while all controls showed increased lumbar and femur BMD (P=0.024 and P=0.023). The femur neck BMD z-scores decreased from -0.49+/-1.14 to -1.63+/-1.50 (P=0.032). At the end of therapy, five patients (56%) showed femur neck BMD z-scores below -2.0.CONCLUSION:
The bone metabolism is disturbed during therapy in children with osteosarcoma, resulting in a reduced BMD with respect to healthy controls. Since a reduced BMD predisposes to osteoporosis, specific attention and therapeutic interventions should be considered.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoporose
/
Coluna Vertebral
/
Osteossarcoma
/
Absorciometria de Fóton
/
Densidade Óssea
/
Estudos Retrospectivos
/
Quimioterapia Adjuvante
/
Sobreviventes
/
Tratamento Farmacológico
/
Fêmur
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Criança
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Annals of Pediatric Endocrinology & Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo
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