Effect of GBE50 on action potentials in normal and simulated ischemic guinea pig papillary muscles / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2342-2345, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-262162
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Ginkgo biloba extract 50 (GBE50), a new multicomponent drug with a polyvalent action extracted from the leave of Ginkgo biloba, on the action potentials in normal and simulated ischemic guinea pig papillary muscles.</p><p><b>METHOD</b>Standard intracellular microelectrode technique was used to examine the effects of GBE50 on the action potential parameters [action potential amplitude (APA), overshoot, rest potential, action potential amplitude at 20%, 50%, 90% of repolarization (APD20, APD50, APD90)].</p><p><b>RESULT</b>In normal guinea pig cardiac papillary muscles, GBE50 (20, 50, 100 mg x L(-1)) shortened APD50 and APD90, and did not affect the rest potential parameters. In simulated ischemic guinea pig cardiac papillary cells, action potential duration was significantly shortened, resting potential and action potential amplitude were reduced. 100 mg x L(-1) GBE50 partly attenuated the change induced by ischemia.</p><p><b>CONCLUSION</b>GBE50 shortened APD of normal guinea pig cardiac papillary cells in a concentration-dependent manner. Under ischemia, all action potential parameters were reduced . GBES0 could alleviate the electrophysiological heterogeneity of ischemic myocardium, which may attenuate myocardial ischemia and block the onset of arrhythmia.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Músculos Papilares
/
Fisiologia
/
Potenciais de Ação
/
Extratos Vegetais
/
Distribuição Aleatória
/
Química
/
Isquemia Miocárdica
/
Ginkgo biloba
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS