Chemical constituents from Aster sampsonii / 中国中药杂志

ABSTRACT

From the whole plants of Aster sampsonii, ten compounds were isolated, and were characterized as (4alphaR, 4'alphaR, 5S, 5'S, 9alphaR, 9'alphaR)-4, 4', 4alpha, 4'alpha, 5, 5', 6, 6', 7, 7', 8, 8'-dodecahydro-3, 3', 4alpha, 4'alpha, 5, 5'-hexamethyl-2H, 2'H-9alpha, 9' alpha-binaphtho[2, 3-b]furan-2, 2'-dione(1), furanoligularenone(2), (4alphaR, 5S, 8alphaR)-4alpha, 5, 6, 7, 8, 8alpha-hexahydro-8alpha-hydroxy-3, 4alpha, 5-trimethylnaphtho[2, 3-b]furan-2(4H)-one(3), (4alphaR, 5S, 8alphaS)4alpha, 5, 6, 7, 8, 8alpha-hexahydro-8alpha-hydroxy-3, 4alpha, 5-trimethylnaphtho[2, 3-b]furan-2(4H)-one(4), methyl-1'-hydroxy-2', 6'-dimethoxy-4'-oxocyclohexanacetate(5), 1'-hydroxy-2'-methoxy-4'-oxocyclohexanacetate methyl(6), loliolide (7), jacaranone (8), beta-sitosterol(9), friedeline (10). The structures of all compounds were elucidated on the basis spectroscopic data, including IR, EI-MS, HR-ESI-MS, and 1D and 2D NMR data. The bioassays showed weak sterilization activities for compound 3. Compounds 1-8 were obtained from A. sampsonii for the first time.