CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population / 中华男科学杂志
National Journal of Andrology
;
(12): 420-424, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-262335
ABSTRACT
<p><b>OBJECTIVE</b>To determine the correlation of the CYP1A1 (rs4646422) gene polymorphisms with male infertility in the Chinese Han population.</p><p><b>METHODS</b>Using the Mass ARRAY iPLEX GOLD technique, we conducted a case-control study on theCYPlA1 (rs4646422) gene polymorphisms in 636 infertile males aged 21-49 years (case group) and 442 normal healthy men aged 23-47 years (control group) of the Chinese Han population. We analyzed the genotypes and allele frequencies in the two groups ofsubjects with the SPSS 20.0 software.</p><p><b>RESULTS</b>Compared with the wild homozygous genotype GG, the heterozygous genotype AG (OR = 1.06, 95% CI 0.81-1.38) and homozygous genotype AA (OR = 1.11, 95% CI 0.56-2.21) showed no correlation with male infertility, nor did the mutant allele A (OR = 1.06, 95% CI 0.85-1.32) in comparison with the wild allele G.</p><p><b>CONCLUSION</b>The CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Estudos de Casos e Controles
/
China
/
Citocromo P-450 CYP1A1
/
Alelos
/
Frequência do Gene
/
Genética
/
Genótipo
/
Homozigoto
/
Infertilidade Masculina
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2016
Tipo de documento:
Artigo
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