Variation and significance of serum and stool IL-18 and IFN-gamma levels in children with rotavirus enteritis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 304-306, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-262710
ABSTRACT
<p><b>OBJECTIVE</b>To study the variation and significance of serum and stool IL-18 and IFN-gamma levels in children with rotavirus enteritis.</p><p><b>METHODS</b>Serum and stool specimens from 50 children with acute rotavirus enteritis were collected before treatment. Serum and stool levels of IL-18 and IFN-gamma were measured using ELISA. Serum and stool specimens from 21 age and gender-matched healthy children were used as the Control group.</p><p><b>RESULTS</b>Serum and stool levels of IL-18 and IFN-gamma in patients with rotavirus enteritis were significantly higher than those in the Control group. There was a negative correlation between the serum IFN-gamma level and the frequency of vomiting (r=-0.368, P < 0.05). The stool IL-18 level negatively correlated to the frequency of diarrhea (r=-0.414, P < 0.05). A positive correlation was found between the serum levels of IL-18 and IFN-gamma (r=0.416, P < 0.05).</p><p><b>CONCLUSIONS</b>Serum and stool levels of IL-18 and IFN-gamma were increased and associated with the severity in children with rotavirus enteritis. IL-18 and IFN-gamma might have protective effects against acute rotavirus infection at the early stage.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Infecções por Rotavirus
/
Sangue
/
Química
/
Interferon gama
/
Interleucina-18
/
Enterite
/
Alergia e Imunologia
/
Fezes
Limite:
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2006
Tipo de documento:
Artigo
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