Asparagine synthetase activity in pediatric acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 272-274, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-262719
ABSTRACT
<p><b>OBJECTIVE</b>To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia (ALL).</p><p><b>METHODS</b>The cellular activity of asparagine synthetase was detected by HPLC-FLD and Protein measurement in 28 ALL children (7 cases of T-ALL and 21 cases of B-lymphoid lineage ALL) before chemotherapy.</p><p><b>RESULTS</b>The asparagines synthetase activity levels in T-ALL children were significantly higher than those of the B-lymphoid lineage ALL patients, with the median activity level of 9.3 nM Asn/mg protein/hr vs 5.2 nM Asn/mg protein/hr (P < 0.05). The distribution of the asparagine synthetase activity demonstrated a polymorphism in either T-ALL or B-lymphoid lineage ALL patients.</p><p><b>CONCLUSIONS</b>The cellular activity of asparagines synthetase in ALL patients is presented with a polymorphism distribution. The asparagines synthetase activity levels in T-ALL are significantly higher than in B-lymphoid lineage ALL.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asparaginase
/
Aspartato-Amônia Ligase
/
RNA Mensageiro
/
Proteínas de Fusão Oncogênica
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Subunidade alfa 2 de Fator de Ligação ao Core
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Genética
/
Metabolismo
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2006
Tipo de documento:
Artigo
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