Preparation and characterization of solid dispersions of ginkgolides / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1368-1372, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-263010
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the preparation process of solid dispersions of ginkgolides to improve the drug dissolution.</p><p><b>METHOD</b>The influence of formulation and preparation technology on drug release from solid dispersions was investigated by single factor test. The X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) were used to characterize the solid dispersions of ginkgolides.</p><p><b>RESULT</b>The solubilization efficiency of solid dispersions using PVP k30 as carrier was better than that taking poloxamer 188 or HPMC as matrix. The results of XRD and DSC showed that ginkgolides existed in solid dispersion at amorphous form or solvates form. The dissolution rate of ginkgolide B in solid dispersion was increased dramatically compared with raw material.</p><p><b>CONCLUSION</b>Solid dispersions could significantly improve solubility and dissolution rate of ginkgolides.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Solubilidade
/
Difração de Raios X
/
Varredura Diferencial de Calorimetria
/
Preparações Farmacêuticas
/
Química
/
Ginkgolídeos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo
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