Studies on chemical constituents in fruit of Alpinia oxyphylla / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 990-993, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-263085
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents in fruit of Alpinia oxyphylla and their cytotoxicities on cancer cell lines.</p><p><b>METHOD</b>Compounds were isolated and purified by various column chromatographic methods. Their structures were determined by physico-chemical properties and spectral analyses. Compound cytotoxicity was assessed by the sulforhodamine B (SRB) assay.</p><p><b>RESULT</b>Eight compounds were obtained from Me2CO-H2O (70%) extract of the fruit of A. oxyphylla and their structures were identified as (9E)-humulene-2, 3; 6, 7-diepoxide (1), 3(12), 7(13), 9(E)-humulatriene-2, 6-diol (2), (-)-oplopanone (3), yakuchinone A (4), yakuchinone B (5), tectochrysin (6), isovanillin (7), (2E, 4E)-6-hydroxy-2, 6-dimethylhepta-2, 4-dienal (8), and the cytotoxicities of compounds 1, 3-5 on cancer cell lines, A549, HT-29 and SGC-7901, were also investigated.</p><p><b>CONCLUSION</b>Compounds 1-3, 7, 8 were isolated for the first time from this genus and compounds 1, 3-5 exhibited no cytotoxicity against three cancer cell lines at a concentration of 10 mg x L(-1).</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Benzaldeídos
/
Flavonoides
/
Medicamentos de Ervas Chinesas
/
Sobrevivência Celular
/
Química
/
Células HT29
/
Alpinia
/
Diarileptanoides
/
Linhagem Celular Tumoral
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS