The effect of Total Dose of Radiation on Normal Colon of Hybird Mice / 대한치료방사선과학회지
Journal of the Korean Society for Therapeutic Radiology
;
: 99-106, 1986.
Artigo
em Inglês
| WPRIM
| ID: wpr-26310
ABSTRACT
Optimal balance between control probability and risk of complication is emphasized even in present time. Although certain incidence of intestinal injury is accepted as an inevitable consequence after abdominopelvic irradiation, these complications still remain as problems. 60 mice were irradiated with 250kVp orthovoltage x-ray machine and 200 rad x5/wk regimen. Histpathologic findings of colorectum and the relationship with occult blood test were analyzed and possible tolerable dose which would be safe from permanent complication was also estimated. Followings are the results:
Mild mucosal and submucosal edema were observed in 1,000 rad irradiated group. Congestion of small vessels was prominent in 2,000 rad irradiated group and infiltration of inflammatory cells was observed in 3,000 rad irradiated group. Denuded mucosa was observed in 3,000 rad irradiated group. Occult blood test is not a proper indicator for rectal denuding or rectal ulcer, but our results suggest the possibility of using this as a relative scale of intestinal damage. Mitotic figures of crypt cells were observed even in 5,000 rad irradiated group, these suggest that the repair capacity of crypt cells are still functioning.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Úlcera
/
Incidência
/
Colo
/
Estrogênios Conjugados (USP)
/
Edema
/
Mucosa
/
Sangue Oculto
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of the Korean Society for Therapeutic Radiology
Ano de publicação:
1986
Tipo de documento:
Artigo
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