Glioblastoma Following Surgery of Cavernous Malformation: Case Report

ABSTRACT

The authors report a case of left parietal glioblastoma developed five years after surgical removal of the frontal cavernous malformation. A 36-year-old woman presented with history of seizure for 13 years and left frontal parasagittal mass on MRI. The mass was removed uneventfully, and the histopathologic examination revealed a cavernous malformation. Her seizure disappeared after the surgery. Five years later, the patient developed new symptoms of right leg weakness and paresthesia. Imaging studies followed by pathological study revealed left parietal, parasagittal glioblastoma, which was located posterior to the previous surgical field. Following surgery, she is now on regular follow up with radiation therapy and chemotherapy. The authors report this rare occurence of the glioblastoma following surgical removal of cavernous malformation with review of pertinent literatures.