Research progress of platelet proteomics - review / 中国实验血液学杂志

ABSTRACT

Human blood platelets play an important role in a variety of basic life processes, and are widely involved in various biological processes in the human body, including inflammation, wound healing and thrombosis etc. As unnuclear cell particles, platelets do not lend themselves to analysis by traditional cell and molecular biology techniques. In contrast, the study of proteomics and the protein complement of a genome will have a major impact on platelet biology. Moreover, platelet proteomics has been used to analyze a variety of complex biological processes in platelet proteome. This article will review the latest progress on platelet proteomics research, such as the proteomics and its related techniques, proteomics associated with platelets (static and activated platelet proteomics, platelet microparticle proteomics, platelet membrane proteomics, platelet phosphorylation proteomics) as well as platelet proteomics and diseases.