The effect of shourong compound formula on levels of dopamine and its metabolites in brain of Parkinson's disease mice induced by reserpine / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of Shourong compound formula on treating Parkinson's disease.</p><p><b>METHOD</b>Parkinson's disease model mice induced by reserpine was used and by HPLC-ED the levels of Dopamine (DA) and its metabolites were determined.</p><p><b>RESULT</b>Madopar could increase the levels of DA in brain of PD mice. The effect of madopar together with Sourong compound formula was better than that of madopar(P < 0.001).</p><p><b>CONCLUSION</b>Shourong compound formula together with madopar has synergic effect on increase of DA level in brain and can reduce clinic dose of madopar so that side effect of madopar can be decreased.</p>