Experiment study of alendronate in the prevention and treatment of aseptic loosening of prosthesis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 365-367, 2008.
Article
em Zh
| WPRIM
| ID: wpr-263684
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of alendronate on the prevention and treatment of aseptic loosening of prosthesis.</p><p><b>METHODS</b>A rat model of particle-induced osteolysis was used. Thirty-xis SD rats were divided into three groups: negative control group, positive control group and experiment group. Alendronate was administered by ig in experiment group. Positive control group and experiment group received intro-articular injections of ultrahigh molecular weight polyethylene (UHMWPE) particles at 4, 6, 8, 10 weeks postoperatively. Negative control group was received injection with mixture solution of mouse serum and PBS only. All animals were sacrificed at 12 weeks after operation for histologic examination. In vitro human peripheral blood mononuclear (PBMC)were separated and cultured and divided into five groups as group A: PBMC group, group B: PBMC and particles,group C:PBMC and particles with 10(-4) mol/L alendronate, group D:PBMC and particles with 10(-5) mol/L alendronate, group E: PBMC and particles with 10(-6) mol/L alendronate. The production of IL-1beta, IL-6, TNF-alpha in each group were tested.</p><p><b>RESULTS</b>Alendronate could prevent particle-induced osteolysis. The production of IL-1beta, IL-6, TNF-alpha was inhibited when alendronate was used.</p><p><b>CONCLUSION</b>Alendronate can inhibit bone absorptive factors expression induced by wear particles and may be used in the prevention and treatment of aseptic loosening of prosthesis.</p>
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Índice:
WPRIM
Assunto principal:
Osteólise
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Cirurgia Geral
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Falha de Prótese
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Citocinas
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Ratos Sprague-Dawley
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Alendronato
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Tratamento Farmacológico
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Prótese Articular
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Articulações
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Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
Zh
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2008
Tipo de documento:
Article