Allelic polymorphism analysis of killer cell immunoglobulin-like receptor gene 3DL2 in Zhejiang Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 339-342, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-263780
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the allelic polymorphism of killer cell immunoglobulin (Ig)-like receptor (KIR) gene 3DL2 in Zhejiang Han population.</p><p><b>METHODS</b>Allelic definition within KIR3DL2 was achieved through using the PCR-sequence specific oligonucleotide probes (PCR-SSOP) method and the specific amplification of exon 3-exon 4 and exon 8-exon 9. Twenty-one digoxigenin-labelled probes were used to the SSOP analysis.</p><p><b>RESULTS</b>Seven alleles of KIR3DL2 were observed, in which KIR3DL2 *002 had the highest allele frequency, 0.57. One sample could not be given the allele combination according to the probe profile.</p><p><b>CONCLUSION</b>The PCR-SSOP method was reliable. There is a distinctive allele frequency of KIR3DL2 in Zhejiang Han population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
China
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Povo Asiático
/
Receptores KIR3DL2
/
Frequência do Gene
/
Genética
/
Genética Populacional
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2006
Tipo de documento:
Artigo
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