With genechip technique to investigate HLA-DQB1 gene polymorphisms in south and north regions of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 238-239, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-263806
ABSTRACT
<p><b>OBJECTIVE</b>To research and compare HLA-DQB1 gene frequency(GF) and polymorphism distribution between south and north population of Chinese in China.</p><p><b>METHODS</b>Combining PCR-sequence specific primers(SSP) and sequence specific oligonucleotide probe(SSOP) techniques and DNA Microarray Kit for HLA-DQB1 Low Res Genotyping from Shenzhen Yi-Shengtang Biological LTD. Co. was used to type HLA-DQB1 gene polymorphisms of 700 individuals living in south China and 320 individuals in north China.</p><p><b>RESULTS</b>We inspected 10 alleles of HLA-DQB1 and got a series of comprehensive and accurate statistic data.</p><p><b>CONCLUSION</b>It is tested that HLA-DQB1*02, 05, 0601, 0602, 0603 gene frequencies are different obviously(P<0.05) between south and north Chinese. And those data will be useful to kinds of research associated with disease relevant and anthropology research.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Variação Genética
/
Sondas de Oligonucleotídeos
/
Antígenos HLA-DQ
/
China
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Povo Asiático
/
Alelos
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2006
Tipo de documento:
Artigo
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