Effect of Kang'ai injection on hepatic fibrosis in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the inhibition role of Kang'ai injection (KAI) in rats with hepatic fibrosis.</p><p><b>METHOD</b>Animal model with liver fibrosis were induced by 0.01% concentration of diethylnitrosamine (DEN). 30 female Wistar rats (160-200 g) were randomly divided into 3 groups the KAI-DEN group, the DEN group and the blank control group. The KAI-DEN group was administered Kang'ai injection (1 mL x k(-1), intraperitoneal injection, once a week) and the DEN group was administered normal saline intraperitoneal injection. HE staining and VG special staining of liver tissue were used to evaluate liver fibrosis.</p><p><b>RESULT</b>Compared with the DEN group, relatively less structural damage and less pseudolobular formation in the KAI-DEN group. Collagen area of the blank control group, the KAI-DEN group and the DEN group were (6.52 +/- 2.64)% , (17.41 +/- 1.112)% and (20.180 +/- 2.519)% , respectively. The difference was statistically significant, P < 0.05.</p><p><b>CONCLUSION</b>Kang'ai injection could inhibit the formation of DEN-induced liver fibrosis.</p>