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Clinical significance of monitoring coagulation- and fibrinolysis-related indexes during catheter-directed thrombolysis for acute lower-extremity deep venous thrombosis / 南方医科大学学报
Journal of Southern Medical University ; (12): 588-591, 2016.
Artigo em Chinês | WPRIM | ID: wpr-263998
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the patterns of changes in serum levels of of D-dimer, fibrinogen (FIB) and fibrin degradation product (FDP) during catheter-directed thrombolysis (CDT) in patients with acute lower-extremity deep venous thrombosis (DVT) and explore their clinical significance.</p><p><b>METHODS</b>From June, 2014 to June, 2015, 50 patients with acute lower-extremity DVT received CDT. The serum concentrations of D-dimer, FIB and FDP were measured before, during and after CDT in all the subjects, with 50 healthy subjects serving as the control group.</p><p><b>RESULTS</b>Compared with the control group, the patients in DVT group showed significantly increased serum levels of D-dimer (29.17±38.67 vs 0.21 ±0.27 µg/mL), FIB (3.66±0.95 vs 3.32±0.65 g/L) and FDP (76.14±131.48 vs 1.08±0.73 µg/mL) before CDT (P<0.05). Based on the effect of CDT, the patients with DVT were divided into recanalization group (n=34) and failed recanalization group (n=16), and the patients with recanalization had significantly increased serum concentration of D-dimer and FDP (P<0.05) and decreased FIB level (P<0.05) compared with those with failed recanalization at 24 h of CDT. D-dimer, FDP, and FIB showed no significant changes in the patients with failed recanalization after the procedure (P>0.05). Correlation analysis showed that serum D-dimer (r=0.66, P<0.05) and FDP (r=0.50, P<0.05) at 24 h of the procedure were positively correlated with the outcomes of CDT.</p><p><b>CONCLUSION</b>Serum levels of D-dimer, FIB and FDP are important indicators for evaluating and predicting the effectiveness of CDT in patients with acute DVT.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Coagulação Sanguínea / Produtos de Degradação da Fibrina e do Fibrinogênio / Fibrinogênio / Estudos de Casos e Controles / Terapia Trombolítica / Doença Aguda / Resultado do Tratamento / Trombose Venosa / Catéteres Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Terapêutica / Coagulação Sanguínea / Produtos de Degradação da Fibrina e do Fibrinogênio / Fibrinogênio / Estudos de Casos e Controles / Terapia Trombolítica / Doença Aguda / Resultado do Tratamento / Trombose Venosa / Catéteres Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2016 Tipo de documento: Artigo