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Expressions of Slug, ZEB1 and KISS-1 in gastric adenocarcinoma and their clinical significance / 南方医科大学学报
Journal of Southern Medical University ; (12): 532-537, 2016.
Artigo em Chinês | WPRIM | ID: wpr-264009
ABSTRACT
<p><b>OBJECTIVE</b>To identify potential markers for predicting invasion, metastasis, and prognosis of gastric adenocarcinoma (GAC).</p><p><b>METHODS</b>The expressions of Slug, ZEB1 and KISS-1 were detected immunohistochemically in 261 GAC tissues and 80 normal gastric tissues.</p><p><b>RESULTS</b>The positivity rates of Slug, ZEB1, and KISS-1 in gastric tissues were 2.5%, 1.3%, and 87.5%, respectively, significantly different from the rates of 62.1%, 28.4%, and 41.1% in GAC tissues (P<0.05). The expression level of Slug was significantly correlated with the depth of invasion, lymph node metastasis, and pTNM stages; the positivity rates of both ZEB1 and KISS-1 were significantly correlated with the tumor grade, depth of invasion, lymph node metastasis and pTNM stages. Slug expression was positively correlated with ZEB1 expression, and KISS-1 expression was inversely correlated with Slug and ZEB1 expressions. Kaplan-Meier analysis showed that the overall survival time of patients with positive expressions of Slug and ZEB1 was significantly shorter than that of the negative patients, and the survival time of patients positive for KISS-1 was significantly longer than the negative patients. COX multivariate analysis showed that positive Slug, ZEB1 and KISS-1 protein expressions and pTNM stages were independent prognostic factors of GAC (P<0.05).</p><p><b>CONCLUSION</b>The abnormal expressions of Slug, ZEB1 and KISS-1 may contribute to the tumorigenesis of GAC and are related with lymph node metastasis, pTNM stages, and prognosis of GAC. The combined detection of Slug, ZEB1, and KISS-1 expression has an important value in predicting the progression and prognosis of GAC.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Neoplasias Gástricas / Fatores de Transcrição / Imuno-Histoquímica / Adenocarcinoma / Modelos de Riscos Proporcionais / Proteínas de Homeodomínio / Progressão da Doença / Estimativa de Kaplan-Meier Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Neoplasias Gástricas / Fatores de Transcrição / Imuno-Histoquímica / Adenocarcinoma / Modelos de Riscos Proporcionais / Proteínas de Homeodomínio / Progressão da Doença / Estimativa de Kaplan-Meier Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2016 Tipo de documento: Artigo