Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I.</p><p><b>METHODS</b>Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also.</p><p><b>RESULTS</b>JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level.</p><p><b>CONCLUSION</b>JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.</p>