Schwann cells transplantation promoted and the repair of brain stem injury in rats / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 212-218, 2003.
Article
em En
| WPRIM
| ID: wpr-264274
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the possibility of Schwann cells transplantation to promote the repair of injured brain stem reticular structure in rats.</p><p><b>METHODS</b>Schwann cells originated from sciatic nerves of 1 to 2-day-old rats were expanded and labelled by BrdU in vitro, transplanted into rat brain stem reticular structure that was pre-injured by electric needle stimulus. Immunohistochemistry and myelin-staining were used to investigate the expression of BrdU, GAP-43 and new myelination respectively.</p><p><b>RESULTS</b>BrdU positive cells could be identified for up to 8 months and their number increased by about 23%, which mainly migrated toward injured ipsilateral cortex. The GAP-43 expression reached its peak in 1 month after transplantation and was significantly higher than that in the control group. New myelination could be seen in destructed brain stem areas.</p><p><b>CONCLUSION</b>The transplantation of Schwann cells can promote the restoration of injured brain stem reticular structure.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Células de Schwann
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Terapêutica
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Transplante
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Ferimentos e Lesões
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Lesões Encefálicas
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Tronco Encefálico
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Bromodesoxiuridina
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Ratos Wistar
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Transplante de Células
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Eletrofisiologia
Limite:
Animals
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2003
Tipo de documento:
Article