Tuberculosis control priorities defined by using cost-effectiveness and burden of disease / 生物医学与环境科学（英文）

ABSTRACT

<p><b>OBJECTIVE</b>To define TB control priorities using cost-effectiveness and burden of disease.</p><p><b>METHODS</b>An assumed cohort of 2,000 cases was set up based on age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity with natural history and DOTS intervention were constructed based on the epidemiological parameters.</p><p><b>RESULTS</b>DOTS reduced 89.19% of YLL, 78.90% of YLD, and 99.98% of infectivity BOD. One DALY could be saved with 45.70 Yuan by DOTS with 3% discount. Sensitivity analysis showed that discount had effect on CER. Weight of age was insensitive to CER. The higher the DOTS cured rate, the more the cost-effectiveness.</p><p><b>CONCLUSIONS</b>DOTS is a good cost-effectiveness TB control strategy. Cost-effectiveness and burden of disease can be used to define TB control priorities.</p>