The effect of basic fibroblast growth factor on the gene expression of decorin by periodontal ligament fibroblasts in culture / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 352-354, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-264419
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of basic fibroblast growth factor (bFGF) on the gene expression of decorin by periodontal ligament fibroblasts (PLFs) in culture, and discuss the effect of bFGF in periodontal regeneration.</p><p><b>METHODS</b>Human PLFs were cultured and stimulated by exogenous bFGF. Gene expression of decorin was assessed by semi-quantitive RT-PCR.</p><p><b>RESULTS</b>The mRNA expression of decorin was suppressed by bFGF and the effect was dose-dependent. When the dose of bFGF increased, the inhibitive effect decreased.</p><p><b>CONCLUSION</b>Decorin has many biological effects. The inhibitive effect may be one of important factors which participate in the healing process of periodontitis, and provide partly theoretical basis of bFGF in periodontal regeneration.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligamento Periodontal
/
Regeneração
/
RNA Mensageiro
/
Fator 2 de Crescimento de Fibroblastos
/
Decorina
/
Fibroblastos
Limite:
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2008
Tipo de documento:
Artigo
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