Clinical significance and relationship of expression of matrix metalloproteinase-2 mRNA with breast cancer metastasis / 中华外科杂志
Chinese Journal of Surgery
;
(12): 599-604, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-264460
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the clinical significance of matrix metalloproteinase-2 (MMP-2) mRNA and the relationship of MMP-2 mRNA expression with breast cancer metastasis.</p><p><b>METHOD</b>Detect MMP-2 mRNA expression of 30 breast cancer, metastatic lymphnode and 116 clinical breast cancer samples by flurence-quantitative RT-PCR and analysis the relativity of MMP-2 mRNA expression with clinical, pathology factors.</p><p><b>RESULTS</b>MMP-2 mRNA expression in 30 metastatic lymphnode is lower than in primary breast cancer (t = -3.293, P < 0.05). The mRNA expression of MMP-2 in tumor > 2 cm is lower than in tumor </= 2 cm (t = 1.936, P < 0.05). The MMP-2 mRNA expression in stage II, III is lower than in stage I (t = 2.466, P < 0.05). The mRNA expression of MMP-2 in more than 4 lymphnodes positive is lower than in lymphnode 1 - 3 positive (t = 3.202, P < 0.05). The MMP-2 mRNA expression is irrelated with tissue grade, pathologic type, ER, PR and Her-2.</p><p><b>CONCLUSIONS</b>MMP-2 mRNA expression is up-regulated in early clinic stage, lymphnode metastatic early stage, and down regulated with tumor progressing. MMP-2 mRNA expression is related with the metastasis of breast cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias da Mama
/
RNA Mensageiro
/
Receptores de Progesterona
/
Receptores de Estrogênio
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Metaloproteinase 2 da Matriz
/
Genética
/
Linfonodos
/
Metástase Neoplásica
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2005
Tipo de documento:
Artigo
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