Effects of Vanadate on Cellular Ca2+ Movements in Guinea Pig Papillary Muscles
Yonsei Medical Journal
;
: 23-30, 1987.
Artigo
em Inglês
| WPRIM
| ID: wpr-26452
ABSTRACT
The effects of vanadate on cellular Ca2+ movements across the sarcolemma of cardiac muscle cells were investigated by measuring the intracellular and extracellular Ca2+ activities of guinea pig papillary muscle with Ca2+-selective electrodes. During the rest period following a steady-state of 2 contractions per second the extracellular Ca2+ concentration was increased over the basal level within a minute. During the rest period Ca2+ was transported across the sarcolemma into the extracellular space. Vanadate decreased the change in extracellular Ca2+ concentration during the rest period implying that the Ca2+ efflux across the sarcolemma was decreased by vanadate. Vanadate increased intracellular Ca2+ activities significantly (from 1.9 X 10(-7) M to 10(-6)M) resulting in an increase in resting tension. These results suggest that vanadate decreases Ca2+ efflux from the cells into the extracellular space by blocking Ca2+ transport across the sarcolemma, possibly blocking the Na+-Ca2+ exchange transport.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Músculos Papilares
/
Vanádio
/
Vanadatos
/
Cálcio
/
Cobaias
/
Canais Iônicos
/
Animais
/
Potenciais da Membrana
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1987
Tipo de documento:
Artigo
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