Intersectin 1: a molecular linker in the central nervous system / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 401-405, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-264649
ABSTRACT
Down syndrome (DS) is the most common cause of cognitive impairment associated with a congenital chromosomal abnormality, trisomy of chromosome 21. Mental retardation and congenital heart defects are key features of DS. All DS individuals develop early-onset Alzheimer's disease-like neuropathology. Intersectin 1 gene is localized on human chromosome 21, the critical region of DS, and it has higher expression in the brain of DS patients than in normal individuals. So fully understanding functions of intersectin 1 is critical for revealing the pathogenesis of DS. Intersectin 1 protein has two isoforms intersectin 1-L and intersectin 1-S. This review will focus on the distribution, expression characters and functions of intersectin 1 in the central nervous system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cromossomos Humanos Par 21
/
Sistema Nervoso Central
/
Biologia Celular
/
Proteínas Adaptadoras de Transporte Vesicular
/
Genética
/
Transtornos Mentais
/
Metabolismo
/
Neurônios
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2008
Tipo de documento:
Artigo
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