The role and the mechanism of gamma-aminobutyric acid during central nervous system development / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 195-200, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-264677
ABSTRACT
gamma -aminobutyric acid (GABA) is an inhibitory neurotransmitter in adult mammalian central nervous system (CNS). During CNS development, the role of GABA is switched from an excitatory transmitter to an inhibitory transmitter, which is caused by an inhibition of calcium influx into postsynaptic neuron derived from release of GABA. The switch is influenced by the neuronal chloride concentration. When the neuronal chloride concentration is at a high level, GABA acts as an excitatory neurotransmitter. When neuronal chloride concentration decreases to some degree, GABA acts as an inhibitory neurotransmitter. The neuronal chloride concentration is increased by Na+-K+-Cl(-)-Cl(-) cotransporters 1 (NKCC1), and decreased by K+-Cl(-) cotransporter 2 (KCC2).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Sinapses
/
Diferenciação Celular
/
Sistema Nervoso Central
/
Cloretos
/
Embriologia
/
Transmissão Sináptica
/
Sinalização do Cálcio
/
Biologia Celular
/
Ácido gama-Aminobutírico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2008
Tipo de documento:
Artigo
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