Methodological study on quality evaluation of rhubarb based on purgative bioassay / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1309-1312, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-264915
ABSTRACT
<p><b>OBJECTIVE</b>To establish a method suitable to determine the purgative biopotency of rhubarb and construct a new quality evaluation pattern of rhubarb.</p><p><b>METHOD</b>A series of factors such as observation index (mass of feces in 10 hours), animal strain (ICR mice), sex (male) and the dose of diphenoxylate complex (50 mg x kg(-1)) was investigated and fixed. The purgative biopotency as well as anthraquinone determination was used to evaluate the quality of different rhubarb samples.</p><p><b>RESULT</b>There wasn't a good linear relationship between the purgative biopotency and content of anthraquinone. The quality difference of rhubarb samples could be well characterized by combination of purgative biopotency determination and anthraquinone determination.</p><p><b>CONCLUSION</b>The purgative biopotency determination can be used in quality control and evaluation of rhubarb.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Controle de Qualidade
/
Rheum
/
Fatores de Tempo
/
Bioensaio
/
Medicamentos de Ervas Chinesas
/
Catárticos
/
Modelos Lineares
/
Química
/
Fatores Sexuais
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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