Effect of glutathione on blood coagulation function / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1612-1616, 2013.
Article
em Zh
| WPRIM
| ID: wpr-264966
Biblioteca responsável:
WPRO
ABSTRACT
The purpose of this study was to investigate the effect of glutathione (GSH) on blood coagulation. The normal plasma samples and mixed plasma samples were taken randomly, and into which the normal dose and different concentration of GSH were added. The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and thrombin time (TT) were detected by using coagulation method before and after treatment with GSH. The detection results of normal plasma and mixed plasma containing GSH of different concentration were compared and analyzed with linear regression. The results showed that the APTT and FIB values of the plasma containing 2.5 mg/L glutathione or more, PT values of the plasma containing 10 mg/L glutathione or more, and TT values of the plasma containing 1250 mg/L glutathione or more were significantly different from those results of normal plasma or mixed plasma (P < 0.01) . There was a linear relation between all of the detection results of PT,APTT, FIB, TT and glutathione concentrations. The results of TT, APTT, PT and FIB detection in patient plasma were statistically different (P < 0.01) before and after treatment with normal concentration GSH. It is concluded that glutathione can influence detection results of coagulation function.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Tempo de Tromboplastina Parcial
/
Farmacologia
/
Plasma
/
Tempo de Protrombina
/
Tempo de Trombina
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Coagulação Sanguínea
/
Fibrinogênio
/
Glutationa
Limite:
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2013
Tipo de documento:
Article