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Recent advances of studies on role of mTOR signaling in aging of hematopoietic and other organ systems-review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1313-1317, 2013.
Artigo em Chinês | WPRIM | ID: wpr-265022
ABSTRACT
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase, which plays an essential role in cell growth, proliferation and survival. mTOR regulates the transcription of mRNA, synthesis of ribosome and gene expression for metabolism. By forming mTOR complex, it regulates cellular activities by phosphorylating its downstream proteins, such as S6 protein kinase and 4E-BP1. In recent years, the role of mTORC1 in regulating aging is gradually recognized. Studies of physiological function and the regulatory mechanisms of mTOR signaling can not only help to better understand the aging mechanism for cells or organs, but also provide insights as to finding potential new drug targets for aging related diseases. This review focuses on recent advances of mTOR and aging related diseases in hematopoietic and other organ systems.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Envelhecimento / Transdução de Sinais / Serina-Treonina Quinases TOR / Sistema Hematopoético / Metabolismo Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Envelhecimento / Transdução de Sinais / Serina-Treonina Quinases TOR / Sistema Hematopoético / Metabolismo Limite: Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2013 Tipo de documento: Artigo