Study on mitochondrial DNA damage in peripheral blood nucleate cells of the workers exposed to acrylonitrile / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 99-101, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-265046
ABSTRACT
<p><b>OBJECTIVE</b>To study the potential aging effect on workers exposed to acrylonitrile (ACN).</p><p><b>METHODS</b>The deletion rates of mitochondrial DNA (mtDNA) in peripheral blood nucleate cells of 47 exposed workers and 47 non-exposed workers (as control), as well as 12 old people and 12 young people were measured with polymerase chain reaction (PCR).</p><p><b>RESULTS</b>The positive rates of mtDNA deletion in peripheral blood nucleate cells were 17.02% in the workers exposed to ACN and 25.00% in group of old people. However, the mtDNA deletion was not detected in the control group and young people.</p><p><b>CONCLUSIONS</b>ACN could induce mtDNA deletion in peripheral blood nucleate cells of the exposed workers. There may be a potential molecular effect of occupational ACN exposure on workers' aging.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Sanguíneas
/
Acrilonitrila
/
Dano ao DNA
/
Envelhecimento
/
DNA Mitocondrial
/
Exposição Ocupacional
/
Toxicidade
Limite:
Adolescente
/
Idoso
/
Aged80
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2003
Tipo de documento:
Artigo
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