Evaluation of nasal absorption for geniposide solution / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the regulation of geniposide nasal absorption.</p><p><b>METHOD</b>We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.</p><p><b>RESULT</b>Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.</p><p><b>CONCLUSION</b>The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).</p>