Evaluation of nasal absorption for geniposide solution / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 839-842, 2009.
Article
em Zh
| WPRIM
| ID: wpr-265358
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the regulation of geniposide nasal absorption.</p><p><b>METHOD</b>We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.</p><p><b>RESULT</b>Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.</p><p><b>CONCLUSION</b>The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Perfusão
/
Soluções
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Administração Intranasal
/
Medicamentos de Ervas Chinesas
/
Cinética
/
Modelos Lineares
/
Nariz
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Sensibilidade e Especificidade
/
Iridoides
/
Difusão
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Article