Studies of in vitro releasing properties on cyclovirobuxine D matrix-type patch / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the drug releasing properties of Cyclovirobuxine D matrix-type patch.</p><p><b>METHOD</b>To prepare Cyclovirobuxine D single-layered and double-layered patch was prepared and the study the drug releasing properties by in vitro releasing and in vitro skin permeation experiments was studied.</p><p><b>RESULT</b>The coefficient of first-order dynamical equation was good for single-layered patch, which means the releasing rate decreased with the amounts of drug decreasing. Nevertheless, Higuchi equation was good for double-layered patch, which means it belonged framing-type releasing system. In-vitro skin permeation experiment showed that zero-order dynamical equation was good for these two patches which indicated all of them abided by Ficks diffusion law.</p><p><b>CONCLUSION</b>The structure of patch can change the drug releasing properties, the double-layered patch can obtain steady releasing and permeating rate because of storage layer releasing.</p>