Phospholipid scramblase 1 / 生理学报
Acta Physiologica Sinica
;
(6): 501-510, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-265422
ABSTRACT
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import into the nucleus, where it binds to genomic DNA. Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation-inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA). PLSCR1 was also shown to interact with several protein kinases including c-Abl, c-Src, protein kinase Cdelta as well as some other proteins such as onzin, suggesting the roles of PLSCR1 in cell signaling. Indeed, the current evidence proposes that PLSCR1 contributes to cell proliferation, differentiation, apoptosis, and plays roles in the pathogenesis of cancers, especially leukemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fosfolipídeos
/
Fisiologia
/
Proteínas Quinases
/
Leucemia
/
Diferenciação Celular
/
Citocinas
/
Apoptose
/
Proteínas de Transferência de Fosfolipídeos
/
Proliferação de Células
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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