Forced running enhances neurogenesis in the hippocampal dentate gyrus of adult rats and improves learning ability / 生理学报
Acta Physiologica Sinica
;
(6): 415-420, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-265435
ABSTRACT
To investigate the effect of forced running in motor-driven wheel on neurogenesis in the hippocampal dentate gyrus (DG) of adult rats, 5-bromo-2-deoxyuridine (BrdU), a thymidine analog was applied to mark cell proliferation. Neuroepthelial stem cell protein (nestin) expression was used to identify neural stem/precursor cells. The BrdU- and nestin-positive cells were examined by immunohistochemical technique. The ability of learning was evaluated by Y-maze test to explore the functional role of the newborn cells in the DG after forced running. It was found that the number of BrdU- and nestin-positive cells in the DG in running groups was significantly increased compared to that in the control group (P<0.05). The effect of forced running on neurogenesis was intensity-dependent. In addition, an improvement of learning ability in Y-maze test was observed after forced running. These findings suggest that forced running in motor-driven wheel could enhance neurogenesis in the hippocampal DG of adult rats and improve learning ability.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Condicionamento Físico Animal
/
Fisiologia
/
Corrida
/
Bromodesoxiuridina
/
Sobrevivência Celular
/
Ratos Sprague-Dawley
/
Aprendizagem em Labirinto
/
Giro Denteado
/
Biologia Celular
/
Nestina
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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