Determination of melamine by high-performance liquid chromatography-mass spectrometry in urinary calculi / 南方医科大学学报
Journal of Southern Medical University
;
(12): 125-127, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-265680
ABSTRACT
<p><b>OBJECTIVE</b>To establish a high-performance liquid chromatography-mass spectrometry (LC/MS)-based method for efficient determination of melamine in urinary calculi in children taking melamine-contaminated formula milk powder.</p><p><b>METHODS</b>LC/MS was employed to determine the contents of melamine in urinary calculi surgically removed from 17 children with a history of taking melamine-contaminated milk powder and in 4 samples of uric acid stone from adults. The positive ionization mode of electro-spray ionization source was used, and the limit of melamine determination was 0.1 mg/kg.</p><p><b>RESULTS</b>No melamine was detected in the 4 uric acid stone samples from adults. Melamine was detected in 4 samples of urinary calculi from the 17 children, with the concentration ranging from 0.8 to 64 mg/lkg.</p><p><b>CONCLUSION</b>LC/MS is simple and effective for detecting melamine in urinary calculi, which is helpful to the treatment and follow-up.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espectrometria de Massas
/
Triazinas
/
Cálculos Urinários
/
Contaminação de Alimentos
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Laticínios
/
Métodos
Limite:
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Artigo
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